Application of 2216-92-4, These common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 Preparation of N-(1-oxo-9Z-octadecenyl)-N-phenylglycine, ethyl ester STR3 Oleoyl chloride (0.01 mole), N-phenylglycine ethyl ester (0.01 mole) and triethylamine (1.4 ml) in tetrahydrofuran (100 ml) was stirred overnight at room temperature. The solvent was removed by rotary evaporator and the residue was dissolved in ethyl acetate (50 ml) and washed with water (50 ml). The ethyl acetate solution was dried over sodium sulfate, filtered and the solvent removed by a nitrogen stream to give an oil which was purified by chromatography on silica gel to give the title compound. Analysis calcd. for C28 H45 NO3 (443.65): C, 75.80; H, 10.22; N, 3.16. C, 75.51; H, 10.32; N, 2.94.
The synthetic route of 2216-92-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; G. D. Searle & Co.; US4551279; (1985); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics