Synthetic Route of 6279-86-3, A common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, molecular formula is C10H16O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of triethyl 1,1, 2-ethanetricarboxylate (3.51 mL, 15.30 mmol) and 2- (4-nitrophenyl)- ethanimidamide hydrochloride (46.95 g, 217.72 mmol) in anhydrous MeOH (300 mL) at room temperature was added NaOMe (3.8. 82 g, 718.49 mmol) and the resulting suspension was refluxed for 16 hours. After cooling to room temperature, the reaction mixture was chilled to 0C, acidified with 6N HCI, and the separated solids collected by suction and rinsed with cold water. Drying under high vacuum at 45C for 6 hours then gave methyl [4, 6-dihydroxy-2- (4-nitrobenzyl)- pyrimidin-5-yl] acetate (56.48 g, 81% yield) as a pale white powder.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER HEALTHCARE AG; WO2005/73234; (2005); A2;,
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