51760-21-5, name is Dimethyl 5-bromoisophthalate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C10H9BrO4
Sodium hydroxide (0.29 g, 7.32 mmol) was added to a suspension of dimethyl 5-bromoisophthalate (2 g, 7.32 mmol) in acetone (30 ml) and water (15 ml) and the reactionstirred at room temperature for 1 hour. A clear solution was achieved at this point. The reaction was stirred overnight at room temperature. The acetone was removed in vacuu and the residual solution extracted with ethyl acetate. The aqueous was then adjusted to pH4 and extracted twice with ethyl acetate. The organic was then washed with brine, dried andconcentrated to give the title compound as a 60 % pure white solid (1.23 g, 2.85 mmol, 38.9% yield). MS (m/z) 259.0/260.9 (bromine isotopes).
The synthetic route of 51760-21-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; DOWDELL, Sarah E.; EIDAM, Hilary Schenck; ELBAN, Mark; FOX, Ryan Michael; HILFIKER, Mark A.; HOANG, Tram H.; KALLANDER, Lara S.; LAWHORN, Brian Griffin; MANNS, Sharada; PHILP, Joanne; WASHBURN, David G.; YE, Guosen; (274 pag.)WO2017/6295; (2017); A1;,
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