Related Products of 39149-80-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39149-80-9, name is tert-Butyl 2-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
a) 1-(1-tert-Butoxycarbonyl-ethyl)-1H-pyrrole-2-carboxylic Acid Methyl Ester A 60% suspension of sodium hydride in mineral oil (0.704 g, 17.6 mmol) was added to anhydrous N,N-dimethylformamide (40 mL). 1H-Pyrrole-2-carboxylic acid methyl ester (2.0 g, 16 mmol) was dissolved in anhydrous N,N-dimethylformamide (8 mL) and added dropwise to the solution containing the sodium hydride over a period of 2 min. Effervescence was observed and the mixture was stirred for 30 min. 2-Bromo-propionic acid tert-butyl ester (4.0 g, 19.2 mmol) was added and the mixture was stirred at 80 C. for 45 min. Upon cooling to 25 C., the mixture was poured into 1.0 M aqueous hydrochloric acid solution (200 mL) and the product was extracted into ethyl acetate (200 mL). The organic phase was washed with saturated aqueous brine solution (50 mL), dried over magnesium sulfate and concentrated in vacuo. Purification by flash column chromatography (Merck silica gel 60, 40-63 muM, 10% ethyl acetate in hexanes) afforded the desired product, 1-(1-tert-butoxycarbonyl-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester (3.8 g, 15 mmol, 94% yield) as clear oil. 1H NMR (400 MHz, CDCl3) delta: 1.45 (9H, s), 1.72 (3H, d, J=6.9 Hz), 3.79 (3H, s), 5.77 (1H, quartet, J=7.4 Hz), 6.18-6.20 (1H, m), 6.98-7.04 (2H, m).
The synthetic route of tert-Butyl 2-bromopropanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ruebsam, Frank; Dragovich, Peter; US2008/227774; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics