Reference of 39149-80-9, These common heterocyclic compound, 39149-80-9, name is tert-Butyl 2-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0151] To a solution of 3-chloro-4-methylaniline (400 mg, 2.83 mmol) in acetone (35 mL) was added tert-butyl 2-bromopropanoate (890 mg, 4.26 mmol), KI (940 mg, 5.66 mmol), and K2CO3 (781 mg, 5.66 mmol). The mixture was heated at 60C under N2 then filtrated and concentrated. The residue was purified using silica gel eluting with PE/EA (2: 1) to give tert-butyl 2-((3-chloro-4-methylphenyl)amino)propanoate (151 mg, 19% yield).
The synthetic route of 39149-80-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle W.H.; CHOURASIA, Aparajita Hoskote; ERDMAN, Paul E.; FUNG, Leah; MERCURIO, Frank; SULLIVAN, Robert; (86 pag.)WO2019/241274; (2019); A1;,
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