In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 653-92-9 as follows. Safety of Methyl 2-bromo-4-fluorobenzoate
To a solution of 5a (2.00 g, 8.58 mmol), Palladium acetate (0.008 g, 0.04 mmol), PPh3 (0.47 g, 1.69 mmol) and p-tolylboronic acid (10 mL) was added 6 mL of 2 M K2CO3. The mixture was refluxed under nitrogen for 5 h, then diluted with ethyl acetate, and washed with water (50 mL * 3) and brine (50 mL * 3).The organic layer was dried over MgSO4. The solvent was removed under reduced pressure.The residue was purified by flash column chromatography with petroleum ether-ethyl acetate (100/1) as eluant. The product was obtained as a yellow oil. Yield: 82.6%. 1H NMR (CDCl3, 400 MHz) delta: 7.53(1H, dd, J1 = 8.4 Hz, J2 = 2.8 Hz, Ph-H), 7.35(1H,dd, J1 = 8.4 Hz, J2 = 5.6 Hz, Ph-H), 7.25-7.16(5H, m, Ph-H), 3.69(3H, s, Ph-COOCH3)2.41(3H, s, Ph-CH3). ESI-MS (m/z): 245.2 [M+1]+.
According to the analysis of related databases, 653-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Da, Ya-Jing; Yuan, Wei-Dong; Xin, Ting; Nie, Yong-Yan; Ye, Ying; Yan, Yi-Jia; Liang, Li-Sha; Chen, Zhi-Long; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7101 – 7111;,
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