Electric Literature of 2905-69-3,Some common heterocyclic compound, 2905-69-3, name is Methyl 2,5-dichlorobenzoate, molecular formula is C8H6Cl2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 4 Synthesis of 2-(2,5-Dichlorophenyl)-5-(pentafluorophenyl)-1,3,4-oxadiazole (10) Part A Synthesis of 2,5-Dichlorobenzohydrazide Into a flask was introduced 30 g (0.1463 mol) methyl 2,5-dichlorobenzoate and 46.89 g (1.463 mol) hydrazine. This was refluxed for 5 hours. The cooled reaction mixture was poured into an excess of water, to precipitate an off-white solid. Filtration and drying under vacuum gave 30 g solid. A 1H-NMR showed that the material was fairly pure 2,5-dichlorobenzohydrazide and was therefore used without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,5-dichlorobenzoate, its application will become more common.
Reference:
Patent; 3M Innovative Properties Company; US7094902; (2006); B2;,
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