Synthetic Route of 24398-88-7, The chemical industry reduces the impact on the environment during synthesis 24398-88-7, name is Ethyl 3-bromobenzoate, I believe this compound will play a more active role in future production and life.
ethyl-4′-methoxy-biphenyl-3-carboxylate (3b) Preparation according to AV1. To the solution of ZnBr2 (0.67 mL, 1.5 M in THF) and NEP (0.17 mL), 4-methoxyphenyl magnesium bromide (1.57 mL, 0.83 M in THF) was added dropwise and then the catalyst solution (0.08 mL) and ethyl-3-bromobenzoate (229 mg, 1.00 mmol) was added. This solution was stirred for 1 hour at room temperature. The conventional reprocessing and purification by column chromatography (pentane/ether 9:1) yielded 3b as a colourless oil (234 mg, 91%).1H NMR (CDCl3, 300 MHz, 25 C.): delta=8.26 (s, 1H), 8.00-7.97 (m, 1H), 7.73-7.70 (m, 1H), 7.56 (d, J=8.8 Hz, 2H), 7.46 (t, J=7.7 Hz, 1H), 6.99 (d, J=8.7 Hz, 2H), 4.41 (q, J=7.1 Hz, 2H), 3.83 (s, 3H), 1.41 (t, J=7.1 Hz, 3H).13C NMR (CDCl3, 75 MHz, 25 C.): delta=166.5, 159.4, 140.9, 132.5, 130.9, 130.8, 128.6, 128.1, 127.6, 127.1, 114.2, 60.9, 55.2, 14.2.IR (KBr): 2981 (w), 1717 (vs), 1610 (m), 1518 (s), 1439 (m), 1367 (w), 1300 (s), 1249 (vs), 1182 (m), 1109 (s), 1049 (m), 1030 (m), 834 (m), 758 (s), 574 (w).MS (70 eV, EI), m/z (%): 256 (100, M+), 241 (9), 228 (11), 211 (20), 183 (10), 168 (6), 139 (12), 105 (3).HRMS m/z: calculated for C16H16O3: 256.1099; found: 256.1097.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-bromobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; knochel, Paul; Gavriushin, Andrei; Kofink, Christiane Charlotte; Manolikakes, Georg; US2010/184977; (2010); A1;,
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