Reference of 711-01-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 711-01-3 as follows.
Example-6; Charge Vitride (sodium dihydro-bis-methoxyethoxy alummate solution in toluene) reducing agent (200 gm) into a dry RBF at 25-35C under nitrogen atmosphere. Cool the Vitrideto 0C-5C. Slowly add toluene (300 ml) into RBF at 0C-5C. Prepare solution of XIII (100 gm) and toluene (200 ml) mixture; add this solution slowly to the reaction mass at 0C-5C. Maintain reaction mass for 10 min at 0C-5C. Raise the temperature to 25C-35C. Maintain the reaction mass for 1 hr at 25C-35C. Check TLC. After TLC complies, cool the reaction mass to 0C-5C. Slowly add saturated ammonium chloride solution to the reaction mass at 0C-5C. Maintain for 10-15 min. at 0C-5C. Filter the salts and wash with toluene (250 ml). Separate the organic layer and aqueous layer. Wash the toluene layer with sodium chloride solution (250ml x 2). Distill toluene out completely under vacuum at or below 70C. Residue weight: 95 gm. (Compound XIV).
According to the analysis of related databases, 711-01-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; APICORE, LLC; KOVI, Ravishanker; RAPOLE, Keshavrao; NAIK, Ashish; KANNAPAN, Jayaraman; MADALA, Muralikrishna; THAKOR, Sanjay, F.; WO2012/162507; (2012); A1;,
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