Some common heterocyclic compound, 150529-73-0, name is Methyl 2-(3-bromophenyl)acetate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-(3-bromophenyl)acetate
A solution of the bromide from preparation 26 (15.0g, 65.0mmol), tributyltin methoxide (28.3ml, 98mmol), isopropenyl acetate (10.8ml, 98.0mmol), palladium(ll) acetate (750mg, 3.30mmol) and tri-orffto-tolylphosphine (2.0g, 6.5 mmol) were stirred together in toluene (75ml) at 100C under nitrogen for 5 hours. After cooling the reaction was diluted with ethyl acetate (1 50ml) and 4M aqueous potassium fluoride solution (90ml) and stirred for 15 minutes. The mixture was filtered through arbocel and the organic phase separated and reduced in vacua. The residue was purified by flash column chromatography silica gel eluting with a solvent gradient of diethyl ether:pentane:dichloromethane (0:100:0 changing to 25:75:0 then to 0:0:100, by volume) to give the title compound as a pale yellow oil (12.6g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 150529-73-0, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/108675; (2004); A1;,
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