Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 3-amino-5-fluorobenzoate
To a solution of methyl 3-amino-S – fluorobenzoate (440mg, 2.6 mmol) in dry DMF (10 mL) was added Nail (187 mg, 7.8 mmol) portionwise, followed by addition of benzyl bromide (1.1 g, 6.5 mmol). The reaction mixture was stirred at 40 C for 1 6hr and concentrated. The resulting residue was purified by column chromatography to give the desired product. MS: 350 (M+1)
The synthetic route of 884497-46-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10626; (2015); A1;,
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