Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 584-74-7, name is Ethyl 2-fluorophenylacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks
Ethyl (2-fluorophenyl)acetate (900 mg, 5 mmol) and 60 % NaH (240 mg, 6 mmol) were dissolved in DMF (25 mL) and cooled to 0C. Cyclopentyl bromide (745 mg, 5 mmol) was added and the reaction was gradually warmed to rt. Reaction was stirred at rt for 16 h and then partitioned between EtOAc (100 mL) and NaHC03 (150 mL). The reaction was washed with brine (150 mL), dried over MgS04 and solvent was removed under reduced pressure. Saponification was conducted by addition of 2 M NaOH (20 mL) and heating at 60C for 16 h. The mixture was then acidified with 2 M aq HC1 and then extracted with EtOAc. The solution was dried over MgS04 and concentrated to give the title compound (yellow solid, 800 mg, 72 %). ? NMR (400 MHz, CDCl3) delta ppm 7.46 (t, .7=6.6 Hz, 1 H), 7.20 – 7.26 (m, 1 H), 7.12 (t, .7=7.5 Hz, 1 H), 7.05 (t, .7=9.2 Hz, 1 H), 3.78 (d, .7=11.0 Hz, 1 H), 2.47 – 2.60 (m, 1 H), 1.93-2.04 (m, 1 H), 1.54-1.75 (m, 3 H), 1.41-1.54 (m, 2 H), 1.29-1.41 (m, 1 H), 0.98-1.12 (m, 1 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
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