Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148547-19-7, name is Methyl 4-bromo-3-methylbenzoate, A new synthetic method of this compound is introduced below., Product Details of 148547-19-7
To methyl 4-bromo-3 -methyl benzoate (92 g, 0.402 mol), (4-methoxyphenyl)boronic acid (61.1 g, 0.402 mol), Na2CO3 (85.2 g, 0.804 mol), and PdCl2(PPh3)2 (1410 mg, 2.01 mmol) was added EtOH (1.23 L) and water (0.61 L). The reaction was then heated to 80 0C for 1 hour. The reaction was cooled to room temperature, 550 ml of water was added, and the mixture was left standing for 1 hour. The resulting solids were filtered and washed with a solution of EtOH and H2O (1:1, 75O mL). The solids were ground using a mortar and pestle, then were slurried in 250 mL H2O at room temperature for 1 h, then were filtered and washed with water (2×125 mL), and were dried to give methyl 4′-methoxy-2- methylbiphenyl-4-carboxylate. IH NMR (CDCl3, 400 MHz) delta 7.95 (s, IH), 7.89 (d, J = 7.9 Hz, IH), 7.29 (d, J = 7.9 Hz, IH), 7.27 (d, J = 8.7 Hz, 2H), 6.98 (d, J = 8.7 Hz, 2H), 3.94 (s, 3H), 3.87 (s, 3H), 2.33 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK & CO., INC.; WO2007/41494; (2007); A2;,
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