Application of 3196-15-4,Some common heterocyclic compound, 3196-15-4, name is Methyl 2-bromobutyrate, molecular formula is C5H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-5-chloro-1,2-oxydiethylene-4-pyrazolin-3-one(300mg, 0.860mmol) in acetonitrile (12 mL ) was added potassium carbonate (300 mg, 2.15 mmol) and methyl-2-bromobutyrate (230muL, 1.72mmol) and the mixture was stirred at room temperature for 23 hours. After completion of the reaction, water (50mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (50mL × 3). After drying the combined organic layers over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography – (ethyl acetate: methanol – Le = 9: 1) to give 5-chloro-4-(8-chloro-2-ethyl-6-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-5-yl)-1,2-oxydiethylene-4-pyrazolin-3-one white solid (231 mg, yield: 64%)
The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; KAKEN PHARMACEUTICAL COMPANY LIMITED; KOBAYASHI, OSAMU; TAKATSUNA, REIKO; NIIKURA, NAOKO; TATENO, TOMOKO; NAKAMURA, SHINJI; HIRAI, KENJI; KOCHI, SHINICHIRO; KAWANISHI, NAOKI; YAMADA, OSAMU; (76 pag.)JP2016/60742; (2016); A;,
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