Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89-91-8, name is Methyl 2,2-dimethoxyacetate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2,2-dimethoxyacetate
Lithium hydroxide monohydrate (89.5 mmol, 3.75 g,1.2 equiv) was added at 0 C to a solution of methyl dimethoxyacetate (74.6 mmol, 10 g, 1 equiv) in dioxane (45 mL) and water (45 mL). The mixture was stirred for 1 h at 0 C and one additional hour at room temperature. Sodium hydroxide (1M aq soln, 75 mL) was subsequently added and the mixture extracted with diethyl ether (3 x 75 mL). The recovered aqueous layer was acidified with hydrogen chloride (6N aq soln) until a pH of 1-2 then the organics extracted with diethyl ether (3 x 75 mL). The combined organic layers were subsequently dried with magnesium sulfate, filtrated and the solvent slowly evaporated under reduced pressure to conduct to the desired carboxylic acid in a quantitative yield. Colorless liquid; Yield: 99%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Munyemana, Francois; George, Isabelle; Devos, Alain; Colens, Alain; Badarau, Eduard; Frisque-Hesbain, Anne-Marie; Loudet, Aurore; Differding, Edmond; Damien, Jean-Marie; Remion, Jeanine; Van Uytbergen, Jacqueline; Ghosez, Leon; Tetrahedron; vol. 72; 3; (2016); p. 420 – 430;,
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