Application of 25542-62-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25542-62-5, name is Ethyl 6-bromohexanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The compound represented by Formula 8-a was synthesized by Reaction 8-1.Ethyl 2-methylacetatoacetate (23.5 g, 163 mmol) and ethyl 6-bromohexanoate (40.0 g, 179 mmol) were stirred in 200 ml of ethanol and liquid sodium ethoxide was added dropwise thereto. The mixture was stirred at 80 C. for 10 h. After completion of the reaction, the solid was filtered off. The filtrate was distilled under reduced pressure and extracted with dichloromethane and a 2 N aqueous solution of hydrochloric acid. The organic layer was treated with anhydrous sodium sulfate and distilled under reduced pressure (47.7 g). After removal of the solvent, 300 ml of water was added, followed by stirring under reflux for 10 h. After completion of the reaction, the reaction solution was extracted with dichloromethane, treated with sodium sulfate, and distilled under reduced pressure (25 g, 71%).1H NMR (400 MHz, CDCl3): delta=10.85 (1H, s), 2.52 (1H, m), 2.36 (2H, m) 2.30 (3H, s), 1.65 (4H, m), 1.35 (4H, m), 1.09 (3H, d)
The synthetic route of Ethyl 6-bromohexanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SFC CO., LTD.; Song, Ju-man; Min, Seon-Gi; Lee, Seung-Soo; Lee, Do-min; Park, Kyung-Hwa; Hwang, Moon-Chan; Shin, Bong-Ki; Je, Jong-Tae; (72 pag.)US10473666; (2019); B2;,
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