Application of 5616-81-9, A common heterocyclic compound, 5616-81-9, name is tert-Butyl 2-(methylamino)acetate, molecular formula is C7H15NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
R2 H R = ISOBUTYL] R”= 9-fluorenylmethyl Sarcosine tert-butyl ester (500 mg, 3.7 mmol), triethylamine (0.3 ml) and N-Fmoc-leucine (1.4 g, 4 mmol) and PyBrop (1.75 g, 3.7 mmol) were added to dichloromethane (16 ml) in a 50 mL round bottomed flask with a magnetic stirring. The reaction mixture was left to stir at room temperature for 2.5 hours under an atmosphere of nitrogen. The solution was washed with dilute citric acid solution, sodium bicarbonate solution, brine, dried (MgSO4), filtered and concentrated under reduced pressure. The crude residue was purified by column chromatography on silica eluting with [30%] ethyl acetate-hexane to produce the dipeptide as a white solid (440 mg, [40%). 1H] NMR [(300MHZ,] CDC13) [57.] 67-7.19 (8H, m, ArH), 5.82-5. 79 (1H, m, NH), 4.70-4. 50 (3H, m, [NCH2] and a-CH), 4.07-3. 58 (3H, m, CHCH2), 3.06-2. 91 (3H, m, NCH3), 1.90-0. 84 [18H, m, [CH2CH (CH3)] 2 and tBu]. 13C NMR (75MHz, [CDC13)] [5173.] 77, 172.03, 156.09, 143.57, 143.37, 140.90, 127.33, 126.71, 124.85, 119.59, 66.72, 49.51, 48.96, 46.78, 41.29, 36.17, 24.20, 23.00, 21.27.
The synthetic route of 5616-81-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UBIQUITOUS TECHNOLOGIES PTY LTD; WO2004/7427; (2004); A1;,
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