Adding a certain compound to certain chemical reactions, such as: 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64123-77-9, Application In Synthesis of Methyl 2-(3-fluorophenyl)acetate
Compound 16 (5 g, 22.92 mmol, 1.0 eq.) Was dissolved in 50 mL of tetrahydrofuran in a 250 mL round bottom flask, LDA (17.19 mL, 34.38 mmol, 1.5 eq.) was added at minus 78 C and stirred at low temperature for 1 hour. To the above reaction system, a tetrahydrofuran solution (50 mL) of compound 15 (3.44 g, 22.92 mmol, 1.0 eq.) was slowly added dropwise. After the dropwise addition, the mixture was stirred at low temperature for 3 hours. Saturated aqueous NH4Cl, quenched with ethyl acetate (40 mL x 3). The combined organic phases were washed with saturated brine (50 mL x 2). The organic phase was dried, dried and purified on a silica gel column (PE: EA = 20: 1) to give a yellow oil 17 (1.0 g, yield: 11.8%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(3-fluorophenyl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Yaoming Kant, Immanuel New Drug Development Co., Ltd.; Wu Xiangyang; Wang Fei; Ao Zhiyong; Yang Kanghui; Wan Shuangyi; Wang Lijuan; (24 pag.)CN106478590; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics