Reference of 3650-78-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3650-78-0, name is Methyl 3-(4-bromophenyl)acrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(R)-3-oxo hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylic acid tert-butyl ester (1.80 g, 7.46 mmol),Methyl 4-bromocinnamate (2.0 g, 8.3 mmol),Palladium acetate (84 mg, 0.37 mmol),2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (320 mg, 0.75 mmol) andCesium carbonate (3.65g, 11.2mmol)Soluble in 1,4-dioxane (20 mL),The reaction was stirred at 100 C for 12 h under a nitrogen atmosphere.Cool to room temperature, filter, filter cake washed with dichloromethane (100 mL),The residue was purified by silica gel column chromatography (PE/EA (V/V)=3/1).The title compound was obtained as a white solid (1.95 g, 65.1%).
The synthetic route of Methyl 3-(4-bromophenyl)acrylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ·geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
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