Adding a certain compound to certain chemical reactions, such as: 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756525-95-8, Recommanded Product: 756525-95-8
[00584] To a 0.14M solution of carboxylic acid (1.0 equiv) in DCM was added HATU (1.5 equiv) and DIPEA (3.0 equiv). The mixture was stirred for 1 h, then amino-PEG-ester (1.0 equiv) was added. The reaction was allowed to stir until consumption of carboxylic acid, as indicated by LCMS. The mixture was poured into H2O and the aqueous phase was extracted with DCM. The combined organic phases were washed with brine, dried with anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford the product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 9-Amino-4,7-dioxanonanoate, and friends who are interested can also refer to it.
Reference:
Patent; REVOLUTION MEDICINES, INC.; SEMKO, Christopher; PITZEN, Jennifer; WANG, Gang; TIBREWAL, Nidhi; AGGEN, James Bradley; THOTTUMKARA, Arun P.; BURNETT, G. Leslie; GLIEDT, Micah James Evans; KISS, Gert; WON, Walter; LEE, Julie Chu-li; GILL, Adrian Liam; (538 pag.)WO2018/204416; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics