Synthetic Route of 2216-92-4,Some common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Prepared according to Example 2 steps 2 and 3 except with ethyl N- phenylglycinate instead of ethyl [N-PHENYLALANINATE.] Title compound was obtained as a yellow solid (74%). 1H NMR [(CDCI3)] [5] 7.46 (d, 2H), 6.64 (d, 2H), 4.12 (q, 2H), 4.01 (s, 2H), 3.30 (s, 3H), 1.17 (t, 3H). [ANAL. CALC.] for [C14H15NO3F6] : C, 46.80 ; H, 4.21 ; N, 3.90. Found: C, 47.78 ; H, 4.06 ; N, 3.86. HRMS [(MH+)] [CALC.] : 360.1047. Found: 360.1034.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Phenylglycine Ethyl Ester, its application will become more common.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics