Adding a certain compound to certain chemical reactions, such as: 61644-18-6, name is Chloromethyl isobutyrate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61644-18-6, Product Details of 61644-18-6
In a reactor equipped with a distillation device, add toluene,100 g (0.55 mol) of ethyl 1-ethyl-3-methylpyrazole-5-carboxylate and 95 g (0.55 mol) of p-tert-butylbenzoacetonitrile, after dehydration under reflux,224g (0.66mol) of sodium ethoxide solution was added dropwise, and the addition was completed within 5h.Low-boiling by-products are separated from the top of the column.After the reaction was completed, the solvent and other boilables were distilled off under reduced pressure, and toluene was recovered.To the residue were added anhydrous acetonitrile and 4.5 g (0.03 mol) of sodium iodide.Add 77.8g (0.57mol) of 1-chloromethyl isobutyrate,Warm to reflux.After the reaction is completed, cool and separate the liquid phase.The solvent was distilled off under reduced pressure,Get 213.7g1- (2- (4- (tert-butyl) phenyl) -2-cyano-1- (1-ethyl-3-methyl-1H-5-pyrazolyl) ethoxy) isobutyric acid Methyl ester,The yield was 95%, in which the content of the E formula was 88.4%.
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Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Zhong Liangkun; Xu Tianming; Huang Hongying; Wei Youchang; (16 pag.)CN110003111; (2019); A;,
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