Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75567-84-9, name is Methyl 3-(4-bromophenyl)propanoate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 3-(4-bromophenyl)propanoate
To a 8 mL sealed tube was added (1S,4S,5R)-5-[[l-cyclopropyl-4-(2,6-dichlorophenyl)- 1H-pyrazol-5-yl]methoxy]-2-azabicyclo[2.2.1]heptane 41g (150 mg, 0.40 mmol, 1.00 equiv.), a solution of methyl 3-(4-bromophenyl)propanoate (116 mg, 0.48 mmol, 1.20 equiv.) in toluene (3 mL), Ru-phos (38 mg, 0.08 mmol, 0.20 equiv.), Ru-phos-precatalyst (68 mg, 0.08 mmol, 0.20 equiv.), and Cs2CO3 (260 mg, 0.80 mmol, 2.00 equiv.). The resulting mixture was heated at 110C overnight. Upon cooling to room temperature, the mixture was diluted with EA (50 mL), washed successively with H2O (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1 :3) to give methyl 3-[4-[(1S,4S,5R)-5-[[l- cyclopropyl-4-(2,6-dichlorophenyl)-1H-pyrazol-5-yl]methoxy]-2-azabicyclo[2.2.1]heptan-2- yl]phenyl]propanoate 43a (108 mg, 50%) as a colorless oil.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75567-84-9.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; (231 pag.)WO2019/55808; (2019); A1;,
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