Adding a certain compound to certain chemical reactions, such as: 5445-17-0, name is Methyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5445-17-0, Formula: C4H7BrO2
General procedure: An appropriate diphenyl diselenide (2.96g, 9.5 mmol) was dissolved in a 1:1 mixture of water and THF (50 mL) under nitrogen gas. NaBH4 (1.79g, 47.5 mmol) was added. The reaction mixture was stirred until the solution turned colorless (1-3 minutes). The reaction mixture was stirred for a further 30 minutes. A solution of a methyl -2-bromoacetate (2.96g, 19.37 mmol) in THF (5 mL) was added through the rubber septum without opening the reaction apparatus. The reaction mixture was stirred at room temperature and monitored via TLC (~4 hours). Subsequently, the solution was stirred for a further 30 minutes on air, then the reaction mixture was diluted with 50 mL of saturated aqueous solution of NH4Cl and extracted with diethyl ether. The combined organic phases were dried over Na2SO4, filtered and the solvent was evaporated under reduced pressure to get the product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ali, Wesam; Wi?cek, Ma?gorzata; ?a?ewska, Dorota; Kurczab, Rafa?; Jastrz?bska-Wi?sek, Magdalena; Sata?a, Grzegorz; Kucwaj-Brysz, Katarzyna; Lubelska, Annamaria; G?uch-Lutwin, Monika; Mordyl, Barbara; Siwek, Agata; Nasim, Muhammad Jawad; Partyka, Anna; Sudo?, Sylwia; Latacz, Gniewomir; Weso?owska, Anna; Kie?-Kononowicz, Katarzyna; Handzlik, Jadwiga; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 740 – 751;,
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