Electric Literature of 39149-80-9, A common heterocyclic compound, 39149-80-9, name is tert-Butyl 2-bromopropanoate, molecular formula is C7H13BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution 9.5 g (0.10 mol) of 2-hydroxypyridine in 250 mL of DMF was added 16.6 g (0.120 mol) of potassium carbonate followed by 25.0 g (0.120 mol) of 2- bromopropionic acid fert-butyl ester. The resulting mixture was stirred at ambient temperature for 7 h then diluted with IL of water. The aqueous phase was extracted with ethyl acetate (3 x 200 mL) and the combined organics were washed with water (2 x 100 mL), brine (100 mL), dried over magnesium sulfate, filtered and evaporated in vacuo. The crude residue was purified by silica gel chromatography eluting with 25% ethyl acetate in hexanes to afford the title compound as a clear gum 16 g (72%). LC-MS: m/z (ES) 224 (MH)+
The synthetic route of 39149-80-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2009/123870; (2009); A1;,
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