Application of 116419-94-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116419-94-4, name is Methyl 4-methyl-3-(trifluoromethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of 4-(bromomethyl)-3-(trifluoromethyl) benzoic acid: Methyl 4-methyl-3-(trifluoromethyl)benzoate (4.0 g, 18.3 mmol) in CCL, (40 mL) with NBS (3.9 g, 22 mmol) and benzoylperoxide with 25% of water (0.55 g, 1.7 mmol) were stirred and heated to reflux for 6 h. Solvent was evaporated, a water solution of K2CO3 was added and product is extracted with EtOAc to obtain a pale yellow solid (7.64 g, 25.7 mmol). Yield = 140% (crude).
The chemical industry reduces the impact on the environment during synthesis Methyl 4-methyl-3-(trifluoromethyl)benzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ORIBASE PHARMA; CHEVE, Gwenael; DAYDE-CAZALS, Benedicte; FAUVEL, Benedicte; BORIES, Cedric; YASRI, Abdelaziz; WO2014/102377; (2014); A1;,
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