In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 927-68-4, name is 2-Bromoethyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H7BrO2
500 mg of the resulting product 6,7-dihydroxy-4- anilinoquinazoline obtained in step 5 of Embodiment 9 was added with 903 mg of 2-bromoethyl acetate, 1.24 g of anhydrous potassium carbonate, 150mg of potassium iodide and 10 ml of dry DMF. The system was reacted overnight at 50C. and followed by TLC until the reaction finished. The reaction solution was diluted with water, extracted with ethyl acetate, washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate and concentrated in vacuum. The crude product was directly put into the next step of reaction without separation.10178] The crude product was dissolved in 20 ml of methanol and then added with 500 mg of KOH. The system was reacted overnight at room temperature and followed by TLC until the reaction finished. The reaction solution was directly concentrated in vacuum and separated by column chromatography to obtain 520 mg of the resulting product 2,2?-(4-(3- ethynylaniline)quinazoline-6,7-diene) di(oxy)diethanol(79%).j0179] ESI mlz 366.0 (M+H)
The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Zhang, Yanmei; Ding, Ke; Liao, Jinxi; Wang, Yican; Chen, Panyu; (27 pag.)US2016/175453; (2016); A1;,
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