Adding a certain compound to certain chemical reactions, such as: 108928-00-3, name is Ethyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108928-00-3, SDS of cas: 108928-00-3
a) step1 : rac-tert-butyl4-(4-(ethoxycarbonyl)-3-fluorophenyl)-2-methylpiperazine-1-carboxylate A solution of ethyl2,4-difluorobenzoate (200 mg, 1.07 mmol) and 2-methylpiperazine (538 mg,5.37 mmol) in DMA (2 ml) was heated to 100C in a microwave reactor for 15 minutes.Ethyl acetate and water was added. The layers were separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were dried over sodium sulfate,filtered and evaporated. A solution of this crude material and triethylamine (131 mg, 180 f..Ll, 1.29mmol) in dichloromethane (2.00 ml) was cooled to 0C. Di-tert-butyl dicarbonate (352 mg, 1.61mmol) in dichloromethane (0.5 ml) was added dropwise. The mixture was stirred at roomtemperature overnight. Water was added. The layers were separated. The aqueous layer was extracted twice with dichloromethane. The combined organic layers were dried oversodiumsulfate, filtered and evaporated. The crude product was purified with flash columnchromatography on silica gel (Eluent: Heptane/ethyl acetate 0 to 20) to provide 155 mg (34 %)of the title compound as a light yellow oil.
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; DAKKA, Amal; GREEN, Luke; KARP, Gary; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PINARD, Emmanuel; QI, Hongyan; RATNI, Hasane; RISHER, Nicole; WEETALL, Marla; WOLL, Matthew; WO2014/209841; (2014); A2;,
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