Related Products of 40872-87-5, A common heterocyclic compound, 40872-87-5, name is Methyl 3-amino-4-chlorobenzoate, molecular formula is C8H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
7-Oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (0.275 g, 1.44 mmol) and methyl 3-amino-4-chlorobenzoate (401 mg, 2.16 mmol) was suspended in DMF (4.5 mL). Triethylamine (728 mg, 7.19 mmol) was added, resulting in a clear, pale yellow solution. HATU (821 mg, 2.16 mmol) was then added. Solid began to precipitate out of solution again after 30 minutes. After stirring at room temperature for 6 hours the thick mixture was diluted with EtOAc. The solid was collected and dried to give methyl 4-chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzoate. (Yield 0.295 g, 822 mumol, 57.2%).
The synthetic route of 40872-87-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
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