Synthetic Route of 431-47-0, These common heterocyclic compound, 431-47-0, name is Methyl 2,2,2-trifluoroacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of TFA-DOPA-OH (19)As seen in FIG. 2, step a, TFA-DOPA-OH (19) is synthesized by adding L-DOPA (39.4 g, 200 mmol), anhydrous MeOH (300 mL), and a magnetic stirring bar to a 1000 ml flask. The mixture was degassed with argon for 30 min, followed by addition of methyl trifluoroacetate (60 mL, 600 mmol) and triethylamine (112 mL, 800 mmol). The mixture was stirred at room temperature overnight. The volatile solvents were reduced by rotary evaporation and the residue was treated with 1 N HCl to a pH of ca. 1 and extracted with EtOAc. The organic layer was washed with 1N HCl and water, dried over MgSO4, and evaporated to give an off-white solid, 51.5 g (95%).
Statistics shows that Methyl 2,2,2-trifluoroacetate is playing an increasingly important role. we look forward to future research findings about 431-47-0.
Reference:
Patent; Northwestern University; US8227628; (2012); B2;,
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