Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, A new synthetic method of this compound is introduced below., Formula: C10H6F3NO2
In a 25 mL reaction tube, add coumarin 151 (45.8 mg, 0.2 mmol), sodium bromide (30.8 mg, 0.3 mmol), sodium bisulfate hydrate (55.2 mg, 0.4 mmol), water (72 mg, 4 mmol) And acetonitrile (2mL), stirred under the irradiation of three 2-watt LED lamps for 17 hours, after the reaction was completed, extracted, dried, filtered, concentrated, and separated by column chromatography to obtain a yellow solid 2q (48mg, 81%);
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China Normal University; Jiang Xuefeng; Lu Lingling; Li Yiming; (19 pag.)CN111138307; (2020); A;,
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