Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426-65-3, name is Ethyl Pentafluoropropionate, A new synthetic method of this compound is introduced below., Computed Properties of C5H5F5O2
Sodium ethoxide (7.49 g, 0.11 mol) was suspended in methyl tert-butyl ether (anhydrous, 200ml) under nitrogen. Ethyl 2,2,3, 3,3-pentafluoropropanoate (14.8 ml, 0.1 mol) was added dropwise with stirring followed by ethyl acetate (10.7 ml, 0.11 mol). Stirring was continued for 45 minutes at ambient temparature, for one hour at 50C and overnight at ambient tempeature. The mixture was cooled to 0C and acidified with HC1 (1M, 80 ml), brine was added (80 ml), the layers were separated, and the aqueous layer was back-extracted with in methyl tert-butyl ether (80 ml). The combined organic layers were dried over Na2S04and concentrated under reduced pressure to yield 14.6 gram (0.062 mol, 62% yield). H-NMR (300 MHz, CDC13): delta 1 1.96 (s), 5.59 (s), 4.11-4.26 (m), 3.70 (m), 1.21-1.29 (m);19F-NMR (282 MHz, CDC13): delta -81.8 (s), -83.3 (s), -122.7 (s), -123.6 (s); MS 189 (M-OCH2CH3)
The synthetic route of 426-65-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INTERVET INTERNATIONAL B.V.; INTERVET INC.; BERGER, Michael; VEIT, Stephan; NIEDERMANN, Hans, Peter; KAPPESSER, Tobias; STUTZ, Alfred; WO2015/177179; (2015); A1;,
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