Reference of 18013-97-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18013-97-3 name is Diethyl 2,5-dibromoterephthalate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 100 mL dry three-necked flask with a magnetic rotor and a condenser, diethyl 2,5-dibromo-terephthalate (3.80 g, 10.0 mmol, 1.0 eq) was added sequentially.Phenylboronic acid (1.21 g, 10.0 mmol, 1.0 eq), tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (570 mg, 0.5 mmol, 0.05 eq),Na2CO3 (2.12 g, 20 mmol, 2.0 eq).Nitrogen gas was distilled three times, then toluene (60.0 mL) and ethanol (20.0 mL) were added.Nitrogen gas was then bubbled for 20 minutes and the mixture was placed in a 90 C oil bath for 36 hours.The mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure.Eluent (petroleum ether / dichloromethane = 3: 1-1: 1) to give 3 as a white solid 256 mg, 7% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2,5-dibromoterephthalate, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; Lou Weiwei; Huang Da; Chen Shaohai; (46 pag.)CN109678906; (2019); A;,
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