Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H7ClO4S
[1406] tert-butyl 4-((4-(methoxycarbonyl)phenyl)sulfonamido)piperidine-1-carboxylate : To a stirred solution of methyl 4-(chlorosulfonyl)benzoate (2.0 g, 8.547 mmol, 1 eq) and triethylamine (3.5 mL, 25.64 mmol, 3.0 eq.) in tetrahydrofuron was added tert-butyl 4-aminopiperidine-1-carboxylate (2.0 g, 10.25 mmol, 1.2 eq) at 0C. The mixture was allowed to warm to room temperature and stirred 18 h. The progress of the reaction was monitored by TLC (50% ethyl acetate in hexane). After completion of reaction, the reaction was diluted with ethyl acetate (200 mL), washed with water (250 mL), brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain crude. The crude was purified by flash chromatography using 30% ethyl acetate in hexane as an eluent to obtain tert-butyl 4-((4-(methoxycarbonyl)phenyl)sulfonamido)piperidine-1-carboxylate. LC-MS (m/z)=299.2 ([M+H]+- Boc group).
The synthetic route of 69812-51-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ferro Therapeutics, Inc.; Jiang, Chun; Chen, Ruihong; Pandey, Anjali; Kalita, Biswajit; Duraiswamy, Athisayamani Jeyaraj; (293 pag.)US2019/263802; (2019); A1;,
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