Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57486-67-6, name is Methyl 2-(2-fluorophenyl)acetate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-(2-fluorophenyl)acetate
Example 15: Synthesis of 3-(2-Chloro-phenyl)-6-(2-fluoro-benzyi)-lH-pyrazolo[3,4-b]- pyrazine; Step 1. Preparation of [6-Chloro-5-( 2-chloro-benzoyl)-pyrazin-2-yl]-( 2-fluoro-phenyl)- acetic add methyl ester; To a solution of sodium hydride (0.175 g, 7 mmol) and (2-Chloro-phenyl)-(3,5-dichloro- pyrazin-2-yl)-methanone (0.86 g, 2.99 mmol) in 5 mL DMF was added (2-Fluoro-phenyl)- acetic acid methyl ester (0.503 g, 2.99 mmol). The reaction mixture was stirred for one hour at RT, and then was quenched by addition of water and aqueous HCl. The aqueous mixture was extracted with methylene chloride, and the combined organic phases were dried over MgSO4, filtered, and evaporated under reduced pressure to give 1.19 g of crude [6-Chloro-5-(2-chloro-benzoyl)-pyrazin-2-yl]-(2-fluoro-phenyl)-acetic acid methyl ester. Mass Spec. M+H = 419.
The synthetic route of 57486-67-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/23105; (2007); A1;,
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