Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35180-01-9, name is Chloromethyl isopropyl carbonate, A new synthetic method of this compound is introduced below., Product Details of 35180-01-9
Step 1: Iodomethyl Isopropyl Carbonate (49B) Chloromethyl isopropyl carbonate (49A) (30.0 g, 0.198 mol) was dissolved in acetone (150 mL), sodium iodide (60.0 g, 0.396 mol) was added to the mixture, stirring at 30 C. for 4 h. The mixture was then filtered and concentrated in vacuo, the residue was purified by silica gel column chromatography (petroleum ether) to afford iodomethyl isopropyl carbonate (49B) as a light yellow liquid (40.4 g, yield: 83.7%). 1H NMR (400 MHz, CDCl3): delta 5.93 (s, 1H), 4.97-4.91 (m, 1H), 1.32 (d, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sichuan Haisco Pharmaceutical Co., Ltd.; QIN, Linlin; LI, Fangqiong; YI, Shixu; LUO, Huadong; LUO, Xinfeng; WAN, Songlin; REN, Lei; LIU, Guoliang; WEI, Yonggang; LIU, Jianyu; TANG, Peng Cho; (121 pag.)US2016/60197; (2016); A1;,
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