Application of 6627-89-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6627-89-0, name is tert-Butyl phenyl carbonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Neat tert-butyl phenyl carbonate (284 mg, 271 uL, 1.46 mmol) was added to a solution of Nu,Nu’- bis(3-aminopropyl)butane-1,4-diamine (296.0 mg, 1.46 mmol) in ethanol (2.0 ml_) and the contents heated to reflux with stirring for 18 hours. The reaction mixture was concentrated to a pale yellow-colorless oil under vacuum and purified by reverse phase HPLC (Method J). Product containing fractions were lyophilized to obtain 221 mg (23%) of the desired product. LC-MS m z 303.3 [M+H+]; retention time = 0.26 minutes (Method 5). 73 mg (8%) Of tert-butyl (2,2-dimethyl-4-oxo-3-oxa-5,9,14-triazaheptadecan-17-yl)carbamate was also obtained; LC-MS m/z 403.4 [M+H+]; retention time = 0.47 minutes (Method 5).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl phenyl carbonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; AHMAD, Omar Khaled; BROWN, Stephen Paul; DIRICO, Kenneth John; DUSHIN, Russell; FILZEN, Gary Frederick; PUTHENVEETIL, Sujiet; STROP, Pavel; SUBRAMANYAM, Chakrapani; TUMEY, Lawrence N.; (402 pag.)WO2018/138591; (2018); A1;,
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