Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6290-49-9, name is Methyl 2-methoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H8O3
To a solution of 5-methoxy-2-(t fluoromethyl)-4-(t methylsilyl)py dine (5 g, 20.06 mmol) in Tetrahydrofuran (10 mL) cooled to -70 C was added dropwise -BuLi in hexane (23.14 mL, 30.1 mmol) over a period of 30 min. After the addition was complete, the mixture was stirred for 1 h. Methyl 2-methoxyacetate (3.13 g, 30.1 mmol) was then added dropwise and the resulting mixture was stirred for 1 h before being allowed to warm to rt. The reaction was quenched with aqueous NH4CI (100 mL) and the mixture was extracted with ethyl acetate (3 x 50mL). The combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by flash chromatography on silica gel (petroleum ether/EtOAc = 19/1 ) to give the title compound 2-methoxy-1 -(3-methoxy-6-(trifluoromethyl)- 4-(trimethylsilyl)pyridin-2-yl)ethanone (5 g, 15.56 mmol, 78 % yield) as a yellow oil. m/z: [M + H]+ Calcd for C13H19F3NO3S1 322.1 ; Found 322
According to the analysis of related databases, 6290-49-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; BARBE, Guillaume; BOHNERT, Gary; CALANDRA, Nicholas; LAMBERT III, Millard Hurst; LU, Hongfu; LOBERA, Mercedes; RAMANJULU, Joshi; REN, Feng; YANG, Ting; (337 pag.)WO2019/63748; (2019); A1;,
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