Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 110104-60-4, name is (E)-Methyl 4-chloro-3-methoxybut-2-enoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H9ClO3
Example-113 Potassium carbonate (95 mg, 0.69 mmol) and methyl (E)-4-chloro-3-methoxy-2-butenoate (114 mg, 0.69 mmol) were added to a solution of 5-chloro-4-(4-chloro-2-fluoro-5-hydroxyphenyl)-1,2-tetramethylene-4-pyrazolin-3-one (200 mg, 0.63 mmol) in DMF (2 mL), followed by stirring at 50 C. for 5 hours. After the reaction was completed, water (20 mL) was added to the reaction solution, and the resultant product was extracted with ethyl acetate (20 mL*2, 10 mL*1). The organic layer was washed with a saturated saline solution, dried over anhydrous magnesium sulfate, and was concentrated under reduced pressure, whereby a pale yellow oily crude product (319 mg) was obtained. This was purified by silica gel column chromatography (ethyl acetate), whereby methyl (E)-4-[2-chloro-5-(5-chloro-3-oxo-1,2-tetramethylene-4-pyrazolin-4-yl)-4-fluorophenyloxy]-3-methoxy-2-butenoate (283 mg, yield: quantitative) was obtained as a pale yellow oily material. 1H-NMR (400 MHz, CDCl3): delta1.87-1.92 (m, 2H), 1.99-2.03 (m, 2H), 3.60-3.62 (m, 2H), 3.69 (s, 3H), 3.72 (s, 3H), 3.80-3.83 (m, 2H), 5.21 (s, 1H), 5.27 (s, 2H), 7.13 (d, J=6.3 Hz, 1H), 7.17 (d, J=9.1 Hz, 1H). 19F-NMR (376 MHz, CDCl3): delta-119 (s, 1F).
According to the analysis of related databases, 110104-60-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KAKEN PHARMACEUTICAL CO., LTD.; SAGAMI CHEMICAL RESEARCH INSTITUTE; KOBAYASHI, Osamu; NIIKURA, Naoko; INOUE, Tomoko; MIZUTA, Satoshi; TAKATSUNA, Reiko; HIRAI, Kenji; SHIROUZU, Kentaro; OBATA, Miyoo; (183 pag.)US2016/24110; (2016); A1;,
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