Electric Literature of 87808-49-9,Some common heterocyclic compound, 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(2) Compound 2 (4.0 g), Compound 3(3.52 g),[1,1′-bis (diphenylphosphino) ferrocene] palladium (II)Dichloromethane adduct (1.43 g)And potassium carbonate (7.24 g)Of N, N-dimethylformamide (80 mL)Under a nitrogen atmosphere,And the mixture was stirred at 80 C. for 6 hours.To the reaction mixture was added diethyl ether (200 mL)And the mixture was stirred, and insoluble matter was removed by filtration.Water and ethyl acetate were added to the filtrate, followed by stirring,And extracted with ethyl acetate.The obtained organic layer was washed with water and saturated brine,Dried and concentrated under reduced pressure.The residue was purified by silica gel column chromatography (hexane: ethyl acetate = 95: 5 to 80:20) to obtain Compound 4 (2.78 g) As a pale yellow viscous substance.
The synthetic route of 87808-49-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma; Sato, Atsushi; Imashiro, Ritsuo; Tuzisima Tosinori, Shuichi; Tanimoto, Koichi; Yamamoto, Yasuo Wang; Nakane, Tetsuya; Erikawa, Chihiro; (123 pag.)JP2018/199673; (2018); A;,
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