Electric Literature of 150529-73-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 150529-73-0, name is Methyl 2-(3-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.
Tributyltin methoxide (28.3 mL, 98 mmol), the product of preparation 17 (15.0 g, 65mol), isopropenyl acetate (10.8 mL, 98 mmol), palladium (ll) acetate (750 mg, 3.30 mmol) and tri-ortho-tolylphosphine (2.0 g, 6.5 mmol) were stirred together in toluene (75 mL) at 100 C for 5 hours. After cooling, the reaction was diluted with ethyl acetate (150 mL) and 4M aqueous potassium fluoride solution (90 mL), and stirred for 15 minutes. The mixture was filtered through Arbocele and the organic phase was separated and concentrated in vacuo. The residue was then purified by column chromatography on silica gel eluting with diethyl ether : pentane, 0: 100 to 25: 75, followed by dichloromethane to give the title compound as a pale yellow oil in 94% yield (12.6 g). H NMR (400MHz, CDCI3) : 8 : 2. 15 (3H, s), 3.61 (2H, s), 3.69 (5H, s), 7.10-7. 13 (2H, m), 7.19 (1H, d), 7.30 (1H, t); LRMS ESI : m/z 229 [M+Na] +
The chemical industry reduces the impact on the environment during synthesis Methyl 2-(3-bromophenyl)acetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/92840; (2005); A1;,
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