Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 185629-32-7, name is Methyl 4-amino-3-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 4-amino-3-fluorobenzoate
3.101. Compound 95: 4-{[4-(Cyclopropanecarbonyl-amino)-l-methyl-lH-imidazo[4,5- c]pyridin-6-yl]-methyl-amino}-3-difluoromethoxy-5-fluoro-benzamide 3.101.1. Step i): 4-Amino-3-fluoro-5-iodo-benzoic acid methyl ester Iodine (1 eq, 3.76 g) is dissolved in EtOH (80 mL) at room temperature followed by the addition of 4-amino-3-fluoro-benzoic acid methyl ester (1 eq, 2.5 g) and silver sulfate (1 eq, 4.61 g). After lh, the silver salts are filtered off and the filtrate is concentrated under reduced pressure. The residue is dissolved in DCM and washed with sat. Na2S203, passed through a phase separator and concentrated to afford the desired product that is used as such in the next step.
According to the analysis of related databases, 185629-32-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; MAMMOLITI, Oscar; QUINTON, Evelyne; JOANNESSE, Caroline, Martine, Andree-Marie; DE BLIECK, Ann; BLANC, Javier; (263 pag.)WO2017/12647; (2017); A1;,
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