Reference of 18469-52-8, These common heterocyclic compound, 18469-52-8, name is Methyl 4-(aminomethyl)benzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To DMF (50 mL) were added methyl 4-(aminomethyl)benzoate (0.015 mol) and K2CO3 (0.025 mol) [45]. The compounds 4a-4j (0.01 mol) in DMF (15 mL) were added dropwise at 0 C over a period of 0.5 h to the stirred reaction mixture, and the reaction was allowed to stir at 40 C for 8 h, then poured slowly into ice water (200 mL) while stirring constantly, and extracted with ethyl acetate (3×100 mL). The combined organic layer was washed with brine (2×50 mL) and dried with Na2SO4. Ethyl acetate was evaporated under reduced pressure to yield the crude products, which were chromatographed on silica gel using ethyl acetate/petroleum ether as an eluent to afford the products 5a-5j.
The synthetic route of 18469-52-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Cai, Jin; Wei, Hongtao; Hong, Kwon Ho; Wu, Xiaoqing; Cao, Meng; Zong, Xi; Li, Lushen; Sun, Chunlong; Chen, Junqing; Ji, Min; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 1 – 13;,
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