Adding a certain compound to certain chemical reactions, such as: 18469-52-8, name is Methyl 4-(aminomethyl)benzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18469-52-8, COA of Formula: C9H11NO2
General procedure: To a solution of III (1 equiv., 0.10 g) in N-methyl-2-pyrrolidone(10 equiv., 0.3 mL) was added corresponding amine (1.2 equiv.) followedby diisopropylethylamine (3 equiv., 0.2 mL) and the reactionmixture was heated at 130 C for 2 h. The reaction mixture wasthen diluted with water and extracted with ethyl acetate. Ethylacetate layer was dried over anhydrous sodium sulphate and concentratedunder vacuum. The crude products so obtained werepurified by preparative TLC using varying proportions of methanolin dichloromethane as the solvent systems to give the desiredproducts compounds 4-8a and 9a in moderate to good yields.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Koul, Summon; Ramdas, Vidya; Barawkar, Dinesh A.; Waman, Yogesh B.; Prasad, Neela; Madadi, Santosh Kumar; Shejul, Yogesh D.; Bonagiri, Rajesh; Basu, Sujay; Menon, Suraj; Reddy, Srinivasa B.; Chaturvedi, Sandhya; Chennamaneni, Srinivas Rao; Bedse, Gaurav; Thakare, Rhishikesh; Gundu, Jayasagar; Chaudhary, Sumit; De, Siddhartha; Meru, Ashwinkumar V.; Palle, Venkata; Chugh, Anita; Mookhtiar, Kasim A.; Bioorganic and Medicinal Chemistry; vol. 25; 6; (2017); p. 1963 – 1975;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics