Application of 27492-84-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27492-84-8 name is Methyl 4-amino-2-methoxybenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of methyl 4-amino-2-methoxybenzoate (2.0 g, 0.0 11 mol) in DCM (50 mL) cooled to 0 C was added triethylamine (3.0 mL, 0.022 mol) and the reaction mixture was stirred for 10 minutes. Acetyl chloride (1.3 g, 0.0 165 mol) was addeddropwise and the reaction was stirred for 3 h. Water (50 mL) was added and the aqueous layer was extracted with DCM (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and volatiles were evaporated to dryness under reduced pressure to give methyl 4-acetamido-2-methoxybenzoate (2.3 g, 0.01 mol, 91% yield) as a light brown solid. ?H NMR (400 MHz, DMSO-d6) oe 10.22 (s,1H), 7.66 (d, J= 8.8 Hz, 1H), 7.47 (d, J= 1.6 Hz, 1H), 7.20 (dd, J 8.4, 2.0 Hz, 1H),3.74-3.79 (m, 6H), 2.07 (s, 3H); LCMS (ESI) m/e 224.2 [(M+H), calcd for C11H14NO4, 224.08]; LC/MS retention time (method B): ti = 1.20 mm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-amino-2-methoxybenzoate, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; MACOR, John E.; BRONSON, Joanne J.; DASGUPTA, Bireshwar; DZIERBA, Carolyn Diane; NARA, Susheel Jethanand; KARATHOLUVHU, Maheswaran Sivasamban; (226 pag.)WO2016/53794; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics