Related Products of 176694-36-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 176694-36-3 name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 8: (S)-4-[[4-[(3,4-Dichlorophenyl)methyl]morpholin-2-yl]methylcarbamoylmethyl- sulfanyl]-3-(trifluoromethyl)benzoic acid methyl ester. A solution of (S)-[4-[(3,4-dichlorophenyl)methyl]morpholin-2- yljmethylcarbamoylmethylsulfanylsodium (Preparation 6) (0.104 g) in DMF (1.0 mL) was added to a stirred solution of methyl-4-fluoro-3-(trifluoromethyl)benzoate (0.080 g) in DMF (0.5 mL) at room temperature and stirred for 16 h. The reaction mixture was then quenched with aqueous sodium bicarbonate and was extracted into DCM (10 mL x 3). The organic layers were combined and washed with water and dried over magnesium sulfate, filtered and concentrated to yield a pale oil which was chromatographed (SiO2: eluent gradient DCM to 5 : 95 methanol/DCM) to yield the subtitle compound as a colourless oil (0.09O g).MS (ES+ve) 551/553 [M+H]+; Retention time: 2.69 min (STANDARD).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-fluoro-3-(trifluoromethyl)benzoate, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; WO2007/11292; (2007); A1;,
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