Adding a certain compound to certain chemical reactions, such as: 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 383-62-0, HPLC of Formula: C4H5ClF2O2
100 mg (0.172 mmol) of example 15A are dissolved in 1.5 ml of anhydrous N,N-dimethylformamide, admixed with 121 mg (0.87 mmol) of potassium carbonate and stirred for 30 min. 68.9 mg (0.435 mmol) of ethyl chloro(difluoro)acetate are added and the mixture is heated to 60 C. for 6 h. Then it is filtered and purified by preparative HPLC with a water/acetonitrile gradient. The product fractions are concentrated to dryness under reduced pressure and the residue is dried under reduced pressure. This affords 21 mg (19% of theory) of the desired compound. 1H NMR (400 MHz, DMSO-d6, delta/ppm): delta=9.0 (t, 1H), 7.6 (d, 1H), 7.05 (b, 2H), 7.5 (d, 2H), 7.3 (d, 1H), 7.2 (d, 1H), 7.05 (t, 1H), 6.3 (t, 1H), 4.85 (m, 1H), 4.2 (t, 1H), 3.9 (m, 1H), 3.6 (t, 2H), 2.0 (s, 3H). LC-MS (Method 4): Rt=2.04 min MS (ESIpos): m/z=510 (M+H)+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-chloro-2,2-difluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER SCHERING PHARMA ATIENGESELLSCHAFT; US2010/298293; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics