Related Products of 52727-57-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52727-57-8 as follows.
a) Methyl 2-amino-5-cyanobenzoate b) Methyl 2-amino-3-ethyl-5-cyanobenzoate A mixture of methyl 2-amino-5-bromobenzoate (4.6 g, 20 mmol), and CuCN (1.97 g, 22 mmol) in NMP (20 mL) was heated to 190 C. and 3 h. The reaction mixture was poured into a solution of ethylene diamine 4 mL) in H2O(16 mL) and extracted with toluene (4*20 mL). The extracts were dried (Na2SO4). Removal of the solvent gave the title compound a) (i.e., R8 is hydrogen). Use of methyl 2-amino-5-bromo-3-ethyl bromobenzoate gave the title compound b) (iLe., R8 is ethyl).
According to the analysis of related databases, 52727-57-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bi, Yingzhi; Yu, Guixue; Rotella, David P.; Macor, John E.; US2002/177587; (2002); A1;,
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