Electric Literature of 764667-64-3,Some common heterocyclic compound, 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, molecular formula is C14H11F3O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
547 gm of 4-oxo-4-[3-(trifiuoromethyl)-556-dihydro[l,2,4]triazolo[4,3-alpha]pyrazin-7(8H)- yl]-l-(2,4,5-trifiuororhohenyl)butan-2-one (Formula V) was obtained by adding 500 gm of 5-[l-hydroxy-2-(2,4,5-trifluorophehy)ethylidene]-2,2-dimethyl-l ,3-dioxane-4,6- dione in to the solution 5000 ml toluene containing 440 gm of ‘ 3-(trifluoromethyl)-5,6,7,8-tetrahydro[l,2,4]triazolo[4,3-?]pyrazine .hydrochloride (Formula VI) and 1100 ml of diisopropyl ethylamine at 25-3O0C followed by heating the reaction mass to toluene reflux temperature till the completion of reaction monitor by TLC or HPLC. Isolation of the above said product done by’, ethylacetate and. aqueous -acidic workup followed by distillation.The isolated compound has been characterized by, Mass and HPLC purity. Mass : 407.18 [M+H]+HPLC purity ‘ . : NLT – 85 %. ‘ ‘ ‘ i
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, its application will become more common.
Reference:
Patent; GLENMARK GENERICS LIMITED; WO2009/84024; (2009); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics