Reference of 6065-82-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6065-82-3 as follows.
Under nitrogen protection, Diethoxyacetate (500 mg, 2.84 mmol) was dissolved in freshly prepared tetrahydrofuranin. When the temperature dropped to -78 C, benzylmagnesium chloride (642 mg, 4.26 mmol) was added. -78 C for 3 hours. When the reaction was warmed to room temperature, the reaction was quenched with a protected aqueous ammonium chloride solution. The organic solvent was removed by rotary evaporation and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution, the organic phase was dried over anhydrous sodium sulfate, filtered,200-300 mesh silica gel column chromatography, 380mg colorless oil, yield 60%.
According to the analysis of related databases, 6065-82-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong University; Li Minyong; Du Lvpei; Jiang Tianyu; (37 pag.)CN105968114; (2016); A;,
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